Tuesday, June 11, 2024
Along with other faculty members, Charles Joseph, MD headed a group of students to create a pilot study for Identifying delay in glymphatic clearance of labeled protons post-acute head trauma utilizing 3D ASL MRI (arterial spin labeling).
“This was a combined effort of Sports Medicine faculty and my research group of students investigating whether we could identify by arterial spin labeling MRI brain injury following concussion and then demonstrate repair with clinical improvement,” Joseph stated.
Traumatic brain injury (TBI) is a major worldwide health concern affecting an estimated 369 per 100,000 people. Ninety percent of injuries are mild (mTBI), defined as a Glasgow Coma Scale score of 13–15/15. Sports-related injuries account for an estimated 17% of injuries; however, the number of cases is underestimated, as the epidemiologic data are derived from hospital admissions, excluding those managed conservatively. All-cause and severity indirect and direct TBI costs were estimated to be $93 billion in 2019 in the US alone, not including lost wages and unemployment. The latter predominantly affects those with moderate or severe TBI. The sequelae after even mild injury may include overt or subtle emotional, cognitive, and endocrinologic dysfunction.
Click HERE to read the full article on the Nature Science Journal website.
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