Biography
Dr. Xu was a research faculty at Oregon Health & Science University and held adjunct teaching positions in several institutions, including George Fox University and Multnomah University. She joined Liberty in 2022 and enjoys teaching undergraduate and graduate courses.
Courses Taught
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BIOL214LG – Human Anatomy & Physiology Lab (GA)
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BIOL224L – General Biology Lab I
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BIOL301L – Genetics Lab
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BIOL403 – Embryology
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BIOL415L – Cell Biology Lab
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BCHM452L – Biochemistry II Lab
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BIOM623 – Human Development Biology
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BIOM710 – Anatomy & Cell Biology – Teaching Prac.
Research Interests
Ovarian biology and physiology, reproductive endocrinology and infertility, fertility preservation
Publications
- Xu J, Kim SY, Mayerhofer A, Bishop CV. Editorial: Small molecules and peptides in paracrine/autocrine regulation of ovarian folliculogenesis. Front Endocrinol (Lausanne). 2023 Mar 3;14:1168701. doi: 10.3389/fendo.2023.1168701. PMID: 36942025; PMCID: PMC10023699. (https://pubmed.ncbi.nlm.nih.gov/36942025/)
- Xu J, Bagnjuk K, Marti-Gutierrez N, Srinivasan S, Mayerhofer A, Lee D, Pejovic T, Mitalipov S, Xu F. Reduced anti-Müllerian hormone action in cumulus-oocyte complexes is beneficial for oocyte maturation without affecting oocyte competence. Front Endocrinol (Lausanne). 2024 Jun 3;15:1365260. doi: 10.3389/fendo.2024.1365260. PMID: 38887270; PMCID: PMC11180751. (https://pubmed.ncbi.nlm.nih.gov/38887270/)
- Du Y, Carranza Z, Luan Y, Busman-Sahay K, Wolf S, Campbell SP, Kim SY, Pejovic T, Estes JD, Zelinski M, Xu J. Evidence of cancer therapy-induced chronic inflammation in the ovary across multiple species: A potential cause of persistent tissue damage and follicle depletion. J Reprod Immunol. 2022 Mar;150:103491. doi: 10.1016/j.jri.2022.103491. Epub 2022 Jan 31. PubMed PMID: 35176661; PubMed Central PMCID: PMC9224575.
- Xu J, Zelinski MB. Oocyte quality following in vitro follicle development†. Biol Reprod. 2022 Feb 22;106(2):291-315. doi: 10.1093/biolre/ioab242. Review. PubMed PMID: 34962509; PubMed Central PMCID: PMC9004734.
- Wang K, Xu F, Maylie J, Xu J. Anti-Müllerian Hormone Regulation of Synaptic Transmission in the Hippocampus Requires MAPK Signaling and Kv4.2 Potassium Channel Activity. Front Neurosci. 2021;15:772251. doi: 10.3389/fnins.2021.772251. eCollection 2021. PubMed PMID: 34975379; PubMed Central PMCID: PMC8716599.
- Xu F, Wolf S, Green O, Xu J. Vitamin D in follicular development and oocyte maturation. Reproduction. 2021 May 5;161(6):R129-R137. doi: 10.1530/REP-20-0608. Review. PubMed PMID: 33835047; PubMed Central PMCID: PMC8105291.
- Xu F, Lawson MS, Bean Y, Ting AY, Pejovic T, De Geest K, Moffitt M, Mitalipov SM, Xu J. Matrix-free 3D culture supports human follicular development from the unilaminar to the antral stage in vitro yielding morphologically normal metaphase II oocytes. Hum Reprod. 2021 Apr 20;36(5):1326-1338. doi: 10.1093/humrep/deab003. PubMed PMID: 33681988; PubMed Central PMCID: PMC8600176.
- Tkachenko OY, Wolf S, Lawson MS, Ting AY, Rodrigues JK, Xu F, Bishop CV, Stouffer RL, Xu J. Insulin-like growth factor 2 is produced by antral follicles and promotes preantral follicle development in macaques†. Biol Reprod. 2021 Mar 11;104(3):602-610. doi: 10.1093/biolre/ioaa227. PubMed PMID: 33348377; PubMed Central PMCID: PMC7962767.
- Woodruff TK, Ataman-Millhouse L, Acharya KS, Almeida-Santos T, Anazodo A, Anderson RA, Appiah L, Bader J, Becktell K, Brannigan RE, Breech L, Bourlon MT, Bumbuliene Ž, Burns K, Campo-Engelstein L, Campos JR, Centola GM, Chehin MB, Chen D, De Vos M, Duncan FE, El-Damen A, Fair D, Famuyiwa Y, Fechner PY, Fontoura P, Frias O, Gerkowicz SA, Ginsberg J, Gracia CR, Goldman K, Gomez-Lobo V, Hazelrigg B, Hsieh MH, Hoyos LR, Hoyos-Martinez A, Jach R, Jassem J, Javed M, Jayasinghe Y, Jeelani R, Jeruss JS, Kaul-Mahajan N, Keim-Malpass J, Ketterl TG, Khrouf M, Kimelman D, Kusuhara A, Kutteh WH, Laronda MM, Lee JR, Lehmann V, Letourneau JM, McGinnis LK, McMahon E, Meacham LR, Mijangos MFV, Moravek M, Nahata L, Ogweno GM, Orwig KE, Pavone ME, Peccatori FA, Pesce RI, Pulaski H, Quinn G, Quintana R, Quintana T, de Carvalho BR, Ramsey-Goldman R, Reinecke J, Reis FM, Rios J, Rhoton-Vlasak AS, Rodriguez-Wallberg KA, Roeca C, Rotz SJ, Rowell E, Salama M, Saraf AJ, Scarella A, Schafer-Kalkhoff T, Schmidt D, Senapati S, Shah D, Shikanov A, Shnorhavorian M, Skiles JL, Smith JF, Smith K, Sobral F, Stimpert K, Su HI, Sugimoto K, Suzuki N, Thakur M, Victorson D, Viale L, Vitek W, Wallace WH, Wartella EA, Westphal LM, Whiteside S, Wilcox LH, Wyns C, Xiao S, Xu J, Zelinski M. A View from the past into our collective future: the oncofertility consortium vision statement. J Assist Reprod Genet. 2021 Jan;38(1):3-15. doi: 10.1007/s10815-020-01983-4. Epub 2021 Jan 6. PubMed PMID: 33405006; PubMed Central PMCID: PMC7786868.
- Pejovic T, Joshi S, Campbell S, Thisted S, Xu F, Xu J. Association between vitamin D and ovarian cancer development in BRCA1 mutation carriers. Oncotarget. 2020 Nov 10;11(45):4104-4114. doi: 10.18632/oncotarget.27803. eCollection 2020 Nov 10. PubMed PMID: 33227068; PubMed Central PMCID: PMC7665231.
- Xu F, Lawson MS, Campbell SP, Tkachenko OY, Park BS, Bishop CV, Xu J. Stage-dependent actions of antimüllerian hormone in regulating granulosa cell proliferation and follicular function in the primate ovary. F S Sci. 2020 Nov;1(2):161-171. doi: 10.1016/j.xfss.2020.10.005. Epub 2020 Oct 13. PubMed PMID: 34355206; PubMed Central PMCID: PMC8329754.
- Wang K, Xu F, Campbell SP, Hart KD, Durham T, Maylie J, Xu J. Rapid actions of anti-Müllerian hormone in regulating synaptic transmission and long-term synaptic plasticity in the hippocampus. FASEB J. 2020 Jan;34(1):706-719. doi: 10.1096/fj.201902217R. Epub 2019 Nov 26. PubMed PMID: 31914642; PubMed Central PMCID: PMC6956706.
- Bagnjuk K, Stöckl JB, Fröhlich T, Arnold GJ, Behr R, Berg U, Berg D, Kunz L, Bishop C, Xu J, Mayerhofer A. Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov. 2019;5:67. doi: 10.1038/s41420-019-0149-7. eCollection 2019. PubMed PMID: 30774995; PubMed Central PMCID: PMC6370808.
- Xu J, Lawson MS, Xu F, Du Y, Tkachenko OY, Bishop CV, Pejovic-Nezhat L, Seifer DB, Hennebold JD. Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary. Front Physiol. 2018;9:1600. doi: 10.3389/fphys.2018.01600. eCollection 2018. PubMed PMID: 30487754; PubMed Central PMCID: PMC6246691.
- Xu J, Lawson MS, Mitalipov SM, Park BS, Xu F. Stage-specific modulation of antimüllerian hormone promotes primate follicular development and oocyte maturation in the matrix-free three-dimensional culture. Fertil Steril. 2018 Nov;110(6):1162-1172. doi: 10.1016/j.fertnstert.2018.07.006. PubMed PMID: 30396561; PubMed Central PMCID: PMC6226025.
- Du Y, Bagnjuk K, Lawson MS, Xu J, Mayerhofer A. Acetylcholine and necroptosis are players in follicular development in primates. Sci Rep. 2018 Apr 18;8(1):6166. doi: 10.1038/s41598-018-24661-z. PubMed PMID: 29670172; PubMed Central PMCID: PMC5906600.
- Xu J, Xu F, Lawson MS, Tkachenko OY, Ting AY, Kahl CA, Park BS, Stouffer RR, Bishop CV. Anti-Müllerian hormone is a survival factor and promotes the growth of rhesus macaque preantral follicles during matrix-free culture. Biol Reprod. 2018 Feb 1;98(2):197-207. doi: 10.1093/biolre/iox181. PubMed PMID: 29293939; PubMed Central PMCID: PMC6248587.
- Baba T, Ting AY, Tkachenko O, Xu J, Stouffer RL. Direct actions of androgen, estrogen and anti-Müllerian hormone on primate secondary follicle development in the absence of FSH in vitro. Hum Reprod. 2017 Dec 1;32(12):2456-2464. doi: 10.1093/humrep/dex322. PubMed PMID: 29077845; PubMed Central PMCID: PMC6075619.
- Lee DM, Thomas CM, Xu F, Yeoman RR, Xu J, Stouffer RL, Wolf DP, Zelinski MB. Subcutaneous ovarian tissue transplantation in nonhuman primates: duration of endocrine function and normalcy of subsequent offspring as demonstrated by reproductive competence, oocyte production, and telomere length. J Assist Reprod Genet. 2017 Nov;34(11):1427-1434. doi: 10.1007/s10815-017-1019-y. Epub 2017 Sep 23. PubMed PMID: 28942525; PubMed Central PMCID: PMC5699995.
- Xu J, Hennebold JD, Seifer DB. Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production. Fertil Steril. 2016 Dec;106(7):1815-1820.e1. doi: 10.1016/j.fertnstert.2016.08.037. Epub 2016 Sep 24. PubMed PMID: 27678030; PubMed Central PMCID: PMC5136302.
- Xu J, Xu F, Letaw JH, Park BS, Searles RP, Ferguson BM. Anti-Müllerian hormone is produced heterogeneously in primate preantral follicles and is a potential biomarker for follicle growth and oocyte maturation in vitro. J Assist Reprod Genet. 2016 Dec;33(12):1665-1675. doi: 10.1007/s10815-016-0804-3. Epub 2016 Sep 15. PubMed PMID: 27638727; PubMed Central PMCID: PMC5234704.
- Xu J, Bishop CV, Lawson MS, Park BS, Xu F. Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates. Hum Reprod. 2016 Jul;31(7):1522-30. doi: 10.1093/humrep/dew100. Epub 2016 May 9. PubMed PMID: 27165618; PubMed Central PMCID: PMC4901882.
- Bishop CV, Xu F, Xu J, Ting AY, Galbreath E, McGee WK, Zelinski MB, Hennebold JD, Cameron JL, Stouffer RL. Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys. Fertil Steril. 2016 Apr;105(4):1023-34. doi: 10.1016/j.fertnstert.2015.11.045. Epub 2015 Dec 21. PubMed PMID: 26718060; PubMed Central PMCID: PMC4821692.
- Xu J, Zelinski MB, Stouffer RL. Studies on anti-Müllerian hormone production, action, and regulation in the primate ovary: insight into human folliculogenesis. In: Tal R, Seifer D, editors. Anti-Mullerian Hormone: Biology, Role in Ovarian Function, and Clinical Significance Hauppauge, New York: Nova Science Publishers; 2016. Chapter 3; p.33-46. 339p.
- Ting AY, Xu J, Stouffer RL. Differential effects of estrogen and progesterone on development of primate secondary follicles in a steroid-depleted milieu in vitro. Hum Reprod. 2015 Aug;30(8):1907-17. doi: 10.1093/humrep/dev119. Epub 2015 Jun 3. PubMed PMID: 26040480; PubMed Central PMCID: PMC4507328.
- Merz C, Saller S, Kunz L, Xu J, Yeoman RR, Ting AY, Lawson MS, Stouffer RL, Hennebold JD, Pau F, Dissen GA, Ojeda SR, Zelinski MB, Mayerhofer A. Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: a marker of growing follicles?. J Ovarian Res. 2015 Mar 7;8:8. doi: 10.1186/s13048-015-0136-4. PubMed PMID: 25824473; PubMed Central PMCID: PMC4356150.
- Rodrigues JK, Navarro PA, Zelinski MB, Stouffer RL, Xu J. Direct actions of androgens on the survival, growth and secretion of steroids and anti-Müllerian hormone by individual macaque follicles during three-dimensional culture. Hum Reprod. 2015 Mar;30(3):664-74. doi: 10.1093/humrep/deu335. Epub 2015 Jan 6. PubMed PMID: 25567619; PubMed Central PMCID: PMC4325670.
- Xu J, McGee WK, Bishop CV, Park BS, Cameron JL, Zelinski MB, Stouffer RL. Exposure of female macaques to Western-style diet with or without chronic T in vivo alters secondary follicle function during encapsulated 3-dimensional culture. Endocrinology. 2015 Mar;156(3):1133-42. doi: 10.1210/en.2014-1711. Epub 2014 Dec 29. PubMed PMID: 25545382; PubMed Central PMCID: PMC4330314.
- Rodrigues JK, Campos JR, Marinho RM, Zelinski MB, Stouffer RL, Xu J. In vitro follicle development and oocyte maturation. In: Marinho RM, Silva AC, Caetano JP, Rodrigues JK, editors. Fertility Preservation Maracanã, Rio de Janeiro, Brazil: MedBook – Editora Científica Ltda; 2015. Chapter 20; p.161-169.
- Xu J. RNA-Seq of macaca mulatta: adult female ovarian follicle. In: Gene Expression in Rhesus Monkey Ovarian Small Antral Follicles Developed in vivo and in vitro. www.ncbi.nlm.nih.gov/sra/?term=SRP044327. Accession number: SRP044327.: NCBI Sequence Read Archive; 2014.
- Fisher TE, Molskness TA, Villeda A, Zelinski MB, Stouffer RL, Xu J. Vascular endothelial growth factor and angiopoietin production by primate follicles during culture is a function of growth rate, gonadotrophin exposure and oxygen milieu. Hum Reprod. 2013 Dec;28(12):3263-70. doi: 10.1093/humrep/det337. Epub 2013 Sep 17. PubMed PMID: 24045779; PubMed Central PMCID: PMC3829578.
- Xu J, Lawson MS, Yeoman RR, Molskness TA, Ting AY, Stouffer RL, Zelinski MB. Fibrin promotes development and function of macaque primary follicles during encapsulated three-dimensional culture. Hum Reprod. 2013 Aug;28(8):2187-200. doi: 10.1093/humrep/det093. Epub 2013 Apr 21. PubMed PMID: 23608357; PubMed Central PMCID: PMC3712659.
- Xu J, Xu M, Bernuci MP, Fisher TE, Shea LD, Woodruff TK, Zelinski MB, Stouffer RL. Primate follicular development and oocyte maturation in vitro. Adv Exp Med Biol. 2013;761:43-67. doi: 10.1007/978-1-4614-8214-7_5. Review. PubMed PMID: 24097381; PubMed Central PMCID: PMC4007769.
- Lee HS, Ma H, Juanes RC, Tachibana M, Sparman M, Woodward J, Ramsey C, Xu J, Kang EJ, Amato P, Mair G, Steinborn R, Mitalipov S. Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep. 2012 May 31;1(5):506-15. doi: 10.1016/j.celrep.2012.03.011. PubMed PMID: 22701816; PubMed Central PMCID: PMC3372871.
- Xu J, Lawson MS, Yeoman RR, Pau KY, Barrett SL, Zelinski MB, Stouffer RL. Secondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotrophins, oxygen and fetuin. Hum Reprod. 2011 May;26(5):1061-72. doi: 10.1093/humrep/der049. Epub 2011 Feb 28. PubMed PMID: 21362681; PubMed Central PMCID: PMC3079470.
- Xu J, Bernuci MP, Lawson MS, Yeoman RR, Fisher TE, Zelinski MB, Stouffer RL. Survival, growth, and maturation of secondary follicles from prepubertal, young, and older adult rhesus monkeys during encapsulated three-dimensional culture: effects of gonadotropins and insulin. Reproduction. 2010 Nov;140(5):685-97. doi: 10.1530/REP-10-0284. Epub 2010 Aug 20. PubMed PMID: 20729335; PubMed Central PMCID: PMC3351200.
- Xu J, Kirigiti MA, Grove KL, Smith MS. Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin. Endocrinology. 2009 Sep;150(9):4231-40. doi: 10.1210/en.2009-0190. Epub 2009 May 21. PubMed PMID: 19470705; PubMed Central PMCID: PMC2736090.
- Xu J, Kirigiti MA, Cowley MA, Grove KL, Smith MS. Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y. Endocrinology. 2009 Jan;150(1):333-40. doi: 10.1210/en.2008-0962. Epub 2008 Aug 21. PubMed PMID: 18719019; PubMed Central PMCID: PMC2630892.
- Xu J, Xu F, Hennebold JD, Molskness TA, Stouffer RL. Expression and role of the corticotropin-releasing hormone/urocortin-receptor-binding protein system in the primate corpus luteum during the menstrual cycle. Endocrinology. 2007 Nov;148(11):5385-95. doi: 10.1210/en.2007-0541. Epub 2007 Aug 9. PubMed PMID: 17690168.
- Xu J, Hennebold JD, Stouffer RL. Dynamic expression and regulation of the corticotropin-releasing hormone/urocortin-receptor-binding protein system in the primate ovary during the menstrual cycle. J Clin Endocrinol Metab. 2006 Apr;91(4):1544-53. doi: 10.1210/jc.2005-2776. Epub 2006 Jan 31. PubMed PMID: 16449328.
- Xu J, Stouffer RL, Searles RP, Hennebold JD. Discovery of LH-regulated genes in the primate corpus luteum. Mol Hum Reprod. 2005 Mar;11(3):151-9. doi: 10.1093/molehr/gah157. Epub 2005 Feb 21. PubMed PMID: 15723857.